Analytical procedures are applied to ensure the identity, strength, quality, purity, and potency of each drug substance and drug product manufactured for human use. Analytical test methods can […]
mRNA in Cell Therapy
In a previous blog (CAT-T + mRNA for Cancer Therapy), we discussed a special cancer therapy in which engineered CAR (chimeric antigen receptor) -T cells and mRNA encoding […]
2023 Layoff Tracker – Data (As of Oct 26, 2023)
Table 1 is a summary of all the layoffs in the biotech industry so far in 2023. Data source: Biopharma Layoff Tracker 2023 on Biospace1. Month Date Company […]
Critical Quality Attributes for mRNA
A Critical Quality Attribute (CQA) is a physical, chemical, biological, or microbiological property or characteristic that should fall within appropriate limits, ranges, or distributions to ensure the desired […]
Different Matrices of Columns: Bead Resin, Fibro, Membrane Adsorber, and Monolith
Chromatography with columns is widely used for the purification of various biomolecules, including RNA. We will examine the differences between bead resin, fibro, membrane adsorber, and monolith. Table […]
Aptamers – Part I
Aptamers are short, single-stranded DNA or RNA molecules that bind to specific target molecules. They are highly versatile and can bind to targets with high selectivity and specificity. […]
Capping of mRNA
Messenger RNA (mRNA) normally consists of five regions in the strand: 5′ cap, 5′ untranslated region (UTR), coding sequence (which includes a non-coding start codon, coding sequence, and […]
Bubble Point
Bubble point of a membrane is the pressure at which air passes through the pores of an already wetted membrane. After the membrane is wetted, a thin layer […]
Nitrogenous Base, Nucleoside, and Nucleotide
The basic building blocks for DNA or RNA are nucleotides. However, there are also other terms that are often confusing. We’ll take a look at the building blocks […]
Self-amplifying mRNA
San Diego-based startup company, Replicate Bioscience, announced on Tuesday, September 12, 2023, that it had begun its first clinical trial on an experimental rabies vaccine using self-amplifying mRNA […]