Here is a incomplete list of siRNA companies for comparison. Company Therapeutic Areas Delivery Platform Pipeline Alnylam Genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) […]
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Alnylam vs. DTx Pharma
On July 17, 2023, DTx Pharma, a preclinical-stage biotech company, announced that it has been acquired by Novartis. It has a platform called “Fatty Acid Ligand Conjugated OligoNucleotide […]
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How to cook mRNA?
Synthesis Method DNA RNA Short Sequence Chemical synthesis with oligo synthesizer Chemical synthesis with oligo synthesizer Long Sequence Chemical synthesis with oligo synthesizer + DNA assembly and cloning […]
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Eleven Therapeutics
On July 17, 2023, Novo Nordisk announced that it would enter into a collaboration with a startup company founded in 2020, Eleven Therapeutics, to “identify new medicines that […]
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Precipitation Method for RNA Purification
Precipitation is a widely adopted method at the bench scale for the purification of various RNA species. It is based on neutralizing the charge of the phosphate backbone […]
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Continuous mRNA Manufacturing
News came out on July 13, 2023, that the “FDA backs new $82M mRNA manufacturing center at MIT” to build a continuous mRNA manufacturing platform. To me, who […]
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Overview of Downstream Purification of mRNA
mRNA purification is a critical step in the manufacturing process of mRNA vaccines and therapeutics. The purification process needs to effectively separate mRNA from both process and product-related […]