Table 1 is a summary of all the layoffs in the biotech industry so far in 2023. Data source: Biopharma Layoff Tracker 2023 on Biospace1. Month Date Company […]
Critical Quality Attributes for mRNA
A Critical Quality Attribute (CQA) is a physical, chemical, biological, or microbiological property or characteristic that should fall within appropriate limits, ranges, or distributions to ensure the desired […]
Different Matrices of Columns: Bead Resin, Fibro, Membrane Adsorber, and Monolith
Chromatography with columns is widely used for the purification of various biomolecules, including RNA. We will examine the differences between bead resin, fibro, membrane adsorber, and monolith. Table […]
Aptamers – Part I
Aptamers are short, single-stranded DNA or RNA molecules that bind to specific target molecules. They are highly versatile and can bind to targets with high selectivity and specificity. […]
Capping of mRNA
Messenger RNA (mRNA) normally consists of five regions in the strand: 5′ cap, 5′ untranslated region (UTR), coding sequence (which includes a non-coding start codon, coding sequence, and […]
Bubble Point
Bubble point of a membrane is the pressure at which air passes through the pores of an already wetted membrane. After the membrane is wetted, a thin layer […]