Here is a incomplete list of siRNA companies for comparison.
| Company | Therapeutic Areas | Delivery Platform | Pipeline |
| Alnylam | Genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases | Lipid nanoparticles (LNPs); Conjugates with GalNAc ligand or short lipid chain | Five approved, multiple in early/late stages |
| DTx Pharma | Peripheral nervous system, muscular and CNS disorders | Conjugates with fatty acids | Four in R&D/preclinical |
| Arrowhead Pharmaceuticals | Intractable diseases, like liver disease, cardiovascular disease, CNS disease, etc. | Conjugates with ligand | Multiple in various stages from preclinical to phase 3 |
| Dicerna | Mainly liver diseases | Conjugates with GalXC ligand | Four in preclinical to phase 2 |
| Silence Therapeutics | Hematology, cardiovascular disease, and rare diseases | Conjugates with GalNAc ligand | Three in preclinical to phase 2 |