Aptamers are short, single-stranded DNA or RNA molecules that bind to specific target molecules. They are highly versatile and can bind to targets with high selectivity and specificity. […]
Capping of mRNA
Messenger RNA (mRNA) normally consists of five regions in the strand: 5′ cap, 5′ untranslated region (UTR), coding sequence (which includes a non-coding start codon, coding sequence, and […]
Bubble Point
Bubble point of a membrane is the pressure at which air passes through the pores of an already wetted membrane. After the membrane is wetted, a thin layer […]
Self-amplifying mRNA
San Diego-based startup company, Replicate Bioscience, announced on Tuesday, September 12, 2023, that it had begun its first clinical trial on an experimental rabies vaccine using self-amplifying mRNA […]
Chemical Synthesis of Oligonucleotides – Part III
For short strands of either RNA or DNA that are around or fewer than 100 nucleotides, chemical synthesis is the most commonly used method. The complete synthesis process […]
CAR-T + mRNA for Cancer Therapy
On Monday, August 21, 2023, the Chinese biotech company CARsgen Therapeutics announced that it will enter a collaboration with the mRNA giant Moderna to combine their solid tumor […]
Chemical Synthesis of Oligonucleotides – Part I
For short strands of either RNA or DNA that are around or less than 100 nucleotides, chemical synthesis is the most commonly used method. The complete synthesis process […]
Chemical Synthesis of Oligonucleotides – Part II
For short strands of either RNA or DNA that are around or less than 100 nucleotides, chemical synthesis is the most commonly used method. The entire process involves […]
Nucleic Acids
The table below provides a brief summary of the different properties of a few common nucleic acids and their applications. Nucleic Acids Messenger RNA (mRNA) Small interfering RNA […]
About siRNA
siRNA, also known as small interfering RNA or silencing RNA, is non-coding double-stranded RNA that operates within the RNA interference (RNAi) pathway. This blog will provide a brief […]